Ketamine Infusion

Ketamine Infusion Therapy

Ketamine is FDA-approved for anesthesia and sedation during procedures medical procedures. Since its approval in 1970, it has been widely used in operating rooms and emergency  departments. A prescription version of ketamine administered through a nasal spray was approved in 2019 by the FDA for   treatment-resistant depression, however, approval for  infusion therapy for the treatment of depression, anxiety, chronic pain  ,  OCD (obsessive-compulsive disorder), Post Traumatic Stress  Disorder (PTSD)  or drug abuse  or alcohol is off-label and has not been approved by the FDA.

Ketamine infusion therapy is still being studied, but research shows that it has a high success rate   when it comes to treating persistent depression, Persistent Post Traumatic Stress Disorder, chronic pain and  debilitating anxiety. The rate of effectiveness makes infusion therapy of ketamine be helpful for people who have not  been able to  achieve  lasting relief through traditional medical solutions.


Ketamine infusions stimulate beneficial brain changes, such as an increase in glutamate that helps strengthen and restore vital neural connections and pathways   in regions  of the brain that are most affected by depression.

Ketamine is also used to treat several chronic pain  syndromes, especially those that have a  neuropathic component. Ketamine in low doses produces strong analgesia in states  of neuropathic pain, presumably due to inhibition of the N-methyl-D-aspartate receptor, although other mechanisms may be involved, including enhancement of  downstream inhibition,  and anti-inflammatory effects at central sites.  Several studies have shown a powerful analgesia during administration, while other studies show long-term analgesic  effects up to 3 months after infusion.


After a complete evaluation and review of your medical history, you as an eligible patient, will receive the treatment. An  intravenous (IV)  line will be started in one limb (arm, hand) so you may receive the ketamine infusion.  Your blood  pressure,  heart rate,  and  oxygen saturation. They will be monitored throughout  the infusion procedure under the supervision of  the doctor. He or she will administer a subanesthetic dose of ketamine,  slowly and continuously. The duration of the Infusion ranges from 40 to 55 minutes for depression, and 2 to 4 hours for chronic pain.

Depending on your response to this first infusion, we may increase the dose incrementally with their  subsequent infusions to maximize their response. We will also often adjust the infusion rate  during each treatment, depending on how you are responding, to maximize effectiveness.    Adjuvant medications may also be administered if needed, such as  anti-nausea  medications  or  mild sedatives for agitation.


Ketamine infusion therapy should be administered and monitored by a provider experienced in a  clinical setting.  In his more than 35 years of experience, 15 of them as a doctor in  the Emergency Department,  Dr. Rengifo has  safely administered ketamine  to many patients, with a variety of conditions, and in a wide range of strengths.  Dr. Rengifo is a member of ASKP, American  Society Of Ketamine Physicians, a  nonprofit group of professionals dedicated to the safe use of Ketamine  for  mental  health disorders and  pain conditions.